DMSA Monograph

Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally administered, metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. It is also known as succimer and sold as a prescription under the trade name Chemet. DMPS chelation is most commonly used to remove lead in both adults and children, although it may also be used for mercury poisoning and for dangerous levels of other heavy metals. Clinical use and research substantiates this compound’s efficacy and safety. 


Meso-2,3-Dimercaptosuccinic Acid (DMSA). Monograph

Altern Med Rev 2000; 5 (3): 264-7

 

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Dimaval®: Scientific Product Monograph

 

Dimaval®: Scientific Product Monograph

The active ingredient of Dimaval®, the sodium salt of (RS)-2,3-bis(sulfanyl)propane-1-sulfonic acid, previously known as (RS)-2,3-Di-mercapto-1- propanesulfonic acid (DMPS), is a complexing agent from the group of vicinal dimercaptans.  Indications: Clinically manifested, chronic and acute poisoning with mercury (metallic mercury, vapor, inorganic and organic compounds); Chronic poisoning with lead.

By virtue of its two vicinal mercaptan groups DMPS can form stable complexes (chelates) with a variety of heavy metals. These chelates are predominantly excreted via the kidneys with the urine. In this way DMPS enhances the excretion of heavy metals, especially of those in the space outside of body cells, i.e. extracelluar space. However, the toxicity of heavy metals is already reduced by complex formation, since heavy metals in the organism are no longer available to block the SH-groups in vital enzymes.  

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Ruprecht J. Dimaval®: Scientific Product Monograph. 7th Edition. Berlin: HEYL Chem.-pharm. Fabrik, 2008.

 

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DMSA Monograph