You are here: Home / Archives for Nutrition / Antioxidants / Lipoic Acid

Role of Mercury Toxicity in Hypertension, Cardiovascular Disease, and Stroke

October 26, 2011 By Leave a Comment

Dr. Mark C. Houston is Associate Clinical Professor of Medicine at Vanderbilt University School of Medicine and Director of the Hypertension Institute at Saint Thomas Hospital in Nashville, TN. He has written an important review article on the cardiovascular consequences of mercury exposure in humans. The article discusses how mercury toxicity in humans is related to hypertension, generalized atherosclerosis, coronary heart disease (CHD), myocardial infarction (MI), cardiac arrhythmias, heart rate variability, sudden death, cerebrovascular accidents (CVA), carotid artery disease, renal dysfunction, and total mortality.

 

Mark C. Houston

Role of Mercury Toxicity in Hypertension, Cardiovascular Disease, and Stroke
J Clin Hypertens (Greenwich) 2011; 13 (8): 621-7

 

ABSTRACT

Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (N-acetyl-L-cysteine, alpha-lipoic acid, L-glutathione), with subsequent decreased oxidant defense and increased oxidative stress. Mercury binds to metallothionein and substitute for zinc, copper, and other trace metals, reducing the effectiveness of metalloenzymes. Mercury induces mitochondrial dysfunction with reduction in adenosine triphosphate, depletion of glutathione, and increased lipid peroxidation. Increased oxidative stress and reduced oxidative defense are common. Selenium and fish containing omega-3 fatty acids antagonize mercury toxicity. The overall vascular effects of mercury include increased oxidative stress and inflammation, reduced oxidative defense, thrombosis, vascular smooth muscle dysfunction, endothelial dysfunction, dyslipidemia, and immune and mitochondrial dysfunction. The clinical consequences of mercury toxicity include hypertension, coronary heart disease, myocardial infarction, cardiac arrhythmias, reduced heart rate variability, increased carotid intima-media thickness and carotid artery obstruction, cerebrovascular accident, generalized atherosclerosis, and renal dysfunction, insufficiency, and proteinuria. Pathological, biochemical, and functional medicine correlations are significant and logical. Mercury diminishes the protective effect of fish and omega-3 fatty acids. Mercury inactivates catecholaminei-0-methyl transferase, which increases serum and urinary epinephrine, norepinephrine, and dopamine. This effect will increase blood pressure and may be a clinical clue to mercury-induced heavy metal toxicity. Mercury toxicity should be evaluated in any patient with hypertension, coronary heart disease, cerebral vascular disease, cerebrovascular accident, or other vascular disease. Specific testing for acute and chronic toxicity and total body burden using hair, toenail, urine, and serum should be performed.

 

Filed Under: Cardiovascular Disease, Health Conditions, Lipoic Acid, Mercury, Stroke Tagged With: , , ,

Intoxication With Heavy Metal As A Possible Cause Of Parkinson’s Disease

August 29, 2011 By Leave a Comment

By veterinarian Hanne Koplev.

Hanne Koplev in the woods

A neurologist recommended in the year 1998, that I should be medicated against my tremor, but I said no thank you to his offer, as I preferred to be better diagnosed before starting medication.

The following year my symptoms increased, as I became more rigid and my tremor got worse and I therefore was easy to persuade by a new neurologist to try anti-Parkinson medication. Shortly after, I was scanned for Parkinson’s disease and the result was compatible with the diagnosis of Parkinson’s disease in the early stage.

Anti-Parkinson medication helped to decrease the symptoms, but soon I experienced more severe symptoms. At first I thought that it was the disease becoming more severe and this was confirmed by my neurologist who told me that it was unavoidable.

After one year on medication my neurologist recommended that I stopped medication before the next consultation. This became the start of a new phase in the way I coped with my disease, as without medication, I experienced that:-

–     The medication can result in abstinences when the medication is stopped.

–     Many of the symptoms, that I thought were Parkinson’s symptoms, were in reality side effects of the medication.

Therefore I decided to accept the symptoms of the disease instead of being burdened with adverse side effects of the medication. The outcome of this choice forced me to search for factors, which had influenced my symptoms.

In the year 2001 I was tested for Heavy Metal Toxicity in a private clinic in Aarhus, Denmark by Dr. Bruce Kyle and I was diagnosed with a combined toxic overload with mercury and copper.

I was treated at Dr. Bruce Kyle’s clinic with the Chelating Agent DMPS, with Vitamin-C infusions and different kinds of antioxidants and nutritional support. At the same time I had my amalgam fillings removed and had non-toxic, non-metal composites instead. This was done by a dentist with extra education in safe removal of amalgam. I also use saunas, which help detoxification by sweating out the toxins through my skin.

After some years of undergoing detoxifying treatments, I had fewer tremors and was less rigid, but I still suffered from fatigue. Allergic reaction against metals was suspect, and I undertook a MELISA-test.  My test showed an allergic reaction against gold, nickel and cadmium and treatment protocol was removal of a dental gold crown, which was replaced with plastic.  Now, I try to avoid nickel and to eat more organic food to avoid cadmium. Luckily I have been rewarded for my efforts as my fatigue has decreased.

Today I can honestly say that testing and treatments for my chronic cumulative toxicity has been successful for revealing some of the causes of my Parkinson’s disease. However, I still have slightly high levels of copper left and in autumn 2006 and spring 2008 tests show that I am also burdened with lead and aluminium.

I don’t dare to think about how my life would have been without detoxifying treatments!  When I look at other patients with Parkinson’s disease who are getting worse, I have even more reasons to be thankful for my health, which continues to improve as time goes on.

Where do these Heavy Metals come from?

In my case, mercury and copper were likely to have come from my amalgam fillings. Copper-amalgam contains a high percentage of copper and I had many fillings in my milk teeth. Even later in school I had many cavities, which were restored with amalgam. The dentist said that I had weak teeth.

As an adult, I have only had one cavity, so I might think that my parents were not good at helping me with tooth brushing and perhaps also the school dentist has been tempted to do fillings, which were not necessary as she was paid for the amount of pupils’ cavities that she restored.

In addition I have in my job as a veterinarian, been exposed to many thermometers, which sometimes break and where the mercury ended up in the bottom of the car. Veterinarians were not properly informed that this could constitute a health hazard at that time.

Moreover mercury can come from vaccinations containing the preservative thiomersal (ethyl-mercury). Mercury might also come from environmental pollution and intake of fish. Copper might come from use of copper spiral (anti contraceptive) and from drinking water and food. The Danish Agriculture Production uses 200 tons of copper yearly and this copper could be assumed to spread to the environment and end up in drinking water and food.

When a person is burdened with mercury toxicity, then the excretion of copper is decreased.

My toxicity burden with lead might perhaps come from common environmental pollution. My toxicity with aluminium probably came from years of injections with aluminium containing products against dust mite allergy.

My nutrition today contains more antioxidants (nutrients which protects the body against free radicals and oxidation), more vegetables (raw vegetables are chosen) and more fruits.  I have stopped eating unhealthy fats such as margarine, hard fats, corn oil, soy, sunflower etc. I try to eat more of the healthy fats such as fat fish (salmon), linseed, olives oil, nuts etc.

I take antioxidants as nutritional supplementation, also a multivitamin mineral pill without iron and copper, extra vitamin C and E, Lipoic acid, N-acetyl-cysteine, Echinacea, Ginkgo Biloba and Coenzyme Q10. I also use DMSA for mercury, copper and lead chelation.

Concerning the nutrition I would recommend the book by Jean Carper – “Your Miracle Brain.”

Physical activity has been an important part of my life. At the beginning of my disease I walked without swinging my right arm and I stumbled rather often. After years training trying to walk normally with swinging my right arm, I have succeeded, but only when I am not too stressed or exhausted. The principle is like this, if I can walk one step with swinging the arm, then I can also walk 3 steps….. or also walk 5 minutes…or 5 kilometres and so on.

I also use visualisation when training my movements.

People, who do not realise the effects that Parkinson’s disease has on their own body, often have problems understanding how demanding it is for a Parkinson patient to cope with conscious movements. Even something as banal as cleaning your shoes on a doormat is not necessarily functioning automatically but needs mental work, like steering a toy car with a joystick.

It is very common that a Parkinson patient with time develops a forward bending posture and some years ago I had thoracic Kyphosis and could not wear any of my shirts anymore. A physiotherapist has taught me some physical exercises, which I since have done every day.

Today my back is straight again, which makes me happy. People, who are happy, often have a straight posture, while sad and grieving people often have a crooked posture. By choosing body posture you can also indirectly choose your emotions.

I enjoy sending a signal that I am bubbling with joys of life.

I try to avoid, if possible, all kind of stress. Now I choose calm classical music instead of rock; I value tight relationships instead of having a circle of acquaintances with ‘small talk’ and I love being out in nature instead of taking city walks. It is a pleasure for me to do meditation and to sing.

I have also improved at listening to the signals from my body and I take care to rest and sleep when needed.  I have also improved at learning to avoid doing things, which I dislike and instead I do things that make me happy.

When being diagnosed with a chronic disease the patient often goes through a life crisis and so did I. The crises made me more religious and I learnt to pray to my God from the bottom of my heart – this has given me spiritual power to cope with life and the new circumstances.

‘Where there is willpower, there is a way to go.’ This phrase was said about me by a good friend, as a way to express how I cope with my disease.

Years ago the neurologists said several times that I had got Parkinson’s disease and that this disease is chronic, impossible to cure and progressive. I thought that it might be like this for other patients, but that it would not be like this in my case. By working and studying a lot and sometimes by choosing blind paths, I have succeeded in finding a tiny little path out of my disease. Today I have fewer symptoms than in the year 1998, which means that the expression ‘progressive’ cannot be used generally about all patients with Parkinson’s disease.

I retired in the year 2001 when I was 44 years old and although it was really a hard time, today I feel that I have a good life. To my co-patients I will say:-  “Search for knowledge and keep on trying to search for new possibilities.”

Generally I recommend neurological patients to be tested with a chelating agent for chronic toxicity with heavy metals. If this is diagnosed, then it is possible to detoxify, which can give hope to a future of increased health and decreased neurological symptoms.

If you want more information about toxicity with heavy metal and Parkinson’s disease then use the Internet.

Thank you for reading my case-story and I wish you all the best.

 

Read More

Bjørklund G.  Parkinson’s Disease and Mercury. Journal of Orthomolekulare Medicine 1995; 10: 147-148.

 

Filed Under: Health Conditions, Lipoic Acid, Mercury, Parkinson's Disease, Patient Stories Tagged With: , ,

Antioxidants Of Growing Interest To Address Infertility, Erectile Dysfunction

July 28, 2011 By Leave a Comment

A growing body of evidence suggests that antioxidants may have significant value in addressing infertility issues in both women and men, including erectile dysfunction, and researchers say that large, specific clinical studies are merited to determine how much they could help. The study this story is based on is available from ScholarsArchive@OSU: http://bit.ly/nNir7E

 

CORVALLIS, Ore. – A growing body of evidence suggests that antioxidants may have significant value in addressing infertility issues in both women and men, including erectile dysfunction, and researchers say that large, specific clinical studies are merited to determine how much they could help.

A new analysis, published online in the journal Pharmacological Research, noted that previous studies on the potential for antioxidants to help address this serious and growing problem have been inconclusive, but that other data indicates nutritional therapies may have significant potential.

The researchers also observed that infertility problems are often an early indicator of other degenerative disease issues such as atherosclerosis, high blood pressure and congestive heart failure. The same approaches that may help treat infertility could also be of value to head off those problems, they said.

The findings were made by Tory Hagen, in the Linus Pauling Institute at Oregon State University, and Francesco Visioli, lead author of the study at the Madrid Institute for Advanced Studies in Spain.

“If oxidative stress is an underlying factor causing infertility, which we think the evidence points to, we should be able to do something about it,” said Hagen, the Jamieson Chair of Healthspan Research in the Linus Pauling Institute. “This might help prevent other critical health problems as well, at an early stage when nutritional therapies often work best.”

The results from early research have been equivocal, Hagen said, but that may be because they were too small or did not focus on antioxidants. Laboratory and in-vitro studies have been very promising, especially with some newer antioxidants such as lipoic acid that have received much less attention.

“The jury is still out on this,” Hagen said. “But the problem is huge, and the data from laboratory studies is very robust, it all fits. There is evidence this might work, and the potential benefits could be enormous.”

The researchers from Oregon and Spain point, in particular, to inadequate production of nitric oxide, an agent that relaxes and dilates blood vessels. This is often caused, in turn, by free radicals that destroy nitric oxide and reduce its function. Antioxidants can help control free radicals. Some existing medical treatments for erectile dysfunction work, in part, by increasing production of nitric oxide.

Aging, which is often associated with erectile dysfunction problems, is also a time when nitric oxide synthesis begins to falter. And infertility problems in general are increasing, scientists say, as more people delay having children until older ages.

“Infertility is multifactorial and we still don’t know the precise nature of this phenomenon,” Visioli said.

If new approaches were developed successfully, the researchers said, they might help treat erectile dysfunction in men, egg implantation and endometriosis in women, and reduce the often serious and sometimes fatal condition of pre-eclampsia in pregnancy. The quality and health of semen and eggs might be improved.

As many as 50 percent of conceptions fail and about 20 percent of clinical pregnancies end in miscarriage, the researchers noted in their report. Both male and female reproductive dysfunction is believed to contribute to this high level of reproductive failure, they said, but few real causes have been identified.

“Some people and physicians are already using antioxidants to help with fertility problems, but we don’t have the real scientific evidence yet to prove its efficacy,” Hagen said. “It’s time to change that.”

Some commonly used antioxidants, such as vitamins C and E, could help, Hagen said. But others, such as lipoic acid, are a little more cutting-edge and set up a biological chain reaction that has a more sustained impact on vasomotor function and health.

Polyphenols, the phytochemicals that often give vegetables their intense color and are also found in chocolate and tea, are also of considerable interest. But many claims are being made and products marketed, the researchers said, before the appropriate science is completed – actions that have actually delayed doing the proper studies.

“There’s a large market of plant-based supplements that requires hard data,” Visioli said. “Most claims are not backed by scientific evidence and human trials. We still need to obtain proof of efficacy before people invest money and hope in preparations of doubtful efficacy.”

About the Linus Pauling Institute: The Linus Pauling Institute at OSU is a world leader in the study of micronutrients and their role in promoting optimum health or preventing and treating disease. Major areas of research include heart disease, cancer, aging and neurodegenerative disease.

 

Filed Under: Antioxidants, Erectile Dysfunction, Health Conditions, Infertility, Lipoic Acid, Other Antioxidants Tagged With: , ,